The film introduces us to Blade, a daywalking human-vampire hybrid vampire hunter. A flashback reveals that he was born in 1967 after his mother had been bitten by a vampire, which forced her to go into labor and caused her death. Flash forward to the present time, a female vampire named Racquel takes a human to a rave club, totally unaware that everyone in the club is a vampire, he realizes this when blood starts to shower down from the sprinkler system. Blade then enters the clubs and starts killing many of the vampires there, save for Quinn, who burns him and tells him "give my regards to Frost".
Quinn later wakes up at the morgue and attacks the examining doctors. One of them, Dr. Karen Jenson escapes and runs into Blade, who had suspected that Quinn would survive. Quinn escapes and Blade takes the bitten Karen to his base of operations. There, Karen meets Abraham Whistler, Blade's aging mentor and weapons technician, who explains to her Blade's mission, the nature of vampires and their clandestine power in society. Whistler injects Karen with garlic serum to halt her transformation into a vampire but Blade warns her that she might still turn.
本片是大片《刀锋战士》(“Blade”)的续集。韦斯利-斯奈普斯(Wesley Snipes)在《刀锋战士》中饰演一个半人半吸血鬼的角色,整天寻思着为了他的出生而复仇,拯救人类免受血腥的阿马吉多顿灾祸(世界末日的战场)。在这次最新的冒险历程中,“刀锋战士”必须与一伙威力强大的吸血鬼联合起来,共同与从未面对过的可怕恶魔----一个全新的超级吸血鬼作战。而这种超级吸血鬼也正在搜寻着这二帮人,意图将他们全部吞噬掉。