Season 1
It sees the start of the working relationship between Los Angeles' FBI department and Charlie Eppes. The main FBI agents are Charlie's brother, Don Eppes, and Terry Lake, as well as David Sinclair. Don and Charlie's father, Alan Eppes, provides emotional support for the pair, while Professor Larry Fleinhardt and doctoral student Amita Ramanujan provide mathematical support and insights to Charlie. Season 1 was a half season, producing only 13 episodes. Sabrina Lloyd played an agent in this season, she was later replaced by Diane Farr.
Season 2
Season two sees several changes to Don's FBI team: Terry Lake is reassigned to Washington and two new members join Don and David Sinclair: Megan Reeves and Colby Granger. Charlie is challenged on one of his long-standing pieces of mathematical work and also starts work on a new theory, Cognitive Emergence Theory. Larry sells his home and lives a nomadic lifestyle, while he becomes romantically involved with Megan. Amita receives an offer for an assistant professor position at Harvard University, but is plagued by doubt as her relationship with Charlie is challenged and her career is in upheaval. Alan begins work and dating again, though he struggles with the loss of his wife, and both he and Charlie have a dream of her. Rob Morrow扮演的FBI探员和他那具备超乎常人数学天才的弟弟Charlie一起侦破了在L.A发生的大范围严重罪案。Charlie对案件独特的思考方式让Don的同僚Terry Lake 和David Sinclair 都感到十分惊讶。与此同时,Don和Charlie的父亲对于两个儿子专注执着的个性会否使彼此在工作中产生摩擦感到担心。Larry Fleinhardt 是Charlie的学院导师,他希望Charlie专注于学术研究而不是浪费无谓的精力帮助警方破案。
NUMB3RS将会通过真实的事例,反映数学理论是如何被应用到警方的调查之中,从而破解一件件匪夷所思的罪案。