In the pilot episode of the show, Grace was about to get married to her boyfriend Danny. When Will disapproved, she became angry and planned to get married secretly anyway. However on the way to the wedding she realizes that Will was right, and she leaves Danny. Needing an apartment, she moved in with Will, in his apartment on the Upper West Side in NYC. Will and Grace spend a lot of time with one another as well as with friends Jack McFarland and Karen Walker. Jack is a flamboyant, gay, struggling stage actor-singer-dancer who, over the course of the show, has a range of jobs including cater waiter, acting teacher, back-up dancer for singers like Jennifer Lopez and Janet Jackson and TV producer. Karen, an alcoholic multimillionaire, works as Grace's assistant, a job she took to have time away from the home she shares with her husband Stan and his kids, Mason and Olivia. Another character who factored into the early episodes of Will & Grace was Will's client Harlin Polk, played by Gary Grubbs. At first he was given billing in the opening credits with the other four cast members, but interest in his storyline waned, and he was written out of the show early in the second season (Harlin, rather reluctantly, fired Will and hired another lawyer).
与经典的《老友记》相似,这部情景喜剧也是讲述发生在四个好朋友之间的种种趣事。自1998年开播以来,也逐渐培养出了一帮很忠实的fans。与《老友记》不同的是,四个主角里两位男性角色都是同性恋……