The Wire employs a broad ensemble cast supplemented by many recurring guest stars to populate the institutions featured in the show. A majority of the cast is African American, which accurately reflects the demographics of Baltimore. However, this is a rarity in American television drama. On February 3, 2008, with the airing of its 55th episode, The Wire became the second-longest running drama with a predominantly African American cast in the history of American prime-time television. Only Soul Food has aired more episodes.
The show's creators are also willing to kill off major characters, so that viewers cannot assume that a given character will survive simply because of a starring role or popularity among fans. In response to a question on why a certain character had to die, David Simon said, "[W]e are not selling hope, or audience gratification, or cheap victories with this show. The Wire is making an argument about what institutions—bureaucracies, criminal enterprises, the cultures of addiction, raw capitalism even—do to individuals. It is not designed purely as an entertainment. It is, I'm afraid, a somewhat angry show."