The series tells the story of Ginji Amano and Ban Mido, a pair of superpowered individuals known as the GetBackers. The duo operates a freelance repossession service (奪還屋, dakkanya?) out of one of the seedier areas of Shinjuku, Tokyo. For a fee, they will recover any lost or stolen item for a client with an "almost 100% success rate".
The GetBackers' job often leads them into bizarre and dangerous situations in order to "get back what shouldn't be gone". Their targets range from lost video games to misplaced components of an atomic bomb. The plot mostly revolves around the their adventures, often complicated by the pair's convoluted, individual pasts and a mysterious place known as the Infinity Fortress.