English

Five years after leaving Los Angeles, Dominic Toretto and his new crew, consisting of his girlfriend Letty, Tego Leo, Rico Santos, Cara Mirtha, and Han Seoul-Oh, are hijacking fuel tankers in the Dominican Republic. Dominic begins to suspect that the police are hot on their trail, after Han informs him that one of his garages have been raided, forcing the crew to disband and go their separate ways. Realizing that he must move, he packs his things in the middle of the night and leaves Letty behind in order to protect her from harm.

Three months later, Dominic is now residing in Panama City. While there, he gets a call from his sister Mia Toretto, who tells him that Letty has been murdered after getting into a car crash. Heartbroken, Dominic heads back to Los Angeles in his red 1970 Chevrolet Chevelle to her funeral to examine Letty's crash and finds traces of nitromethane on the ground. He then goes to the only car mechanic that sells nitromethane and coerces him into giving him the name David Park, the man who ordered the fuel, and informs him that the only car that uses nitromethane is a green 1972 Ford Gran Torino Sport.

Meanwhile, F.B.I. agent Brian O'Conner is trying to track down a drug lord named Arturo Braga. His search leads him to David Park, and he tracks him down using an illegal modification record on his car. Dominic arrives at Park's apartment first and hangs him out of the window by his ankles before letting go. Brian, who was on his way to Park's place, saves Park and Park becomes the F.B.I.'s new informant. Park gets Brian into a street racethrough Los Angeles. Brian selects a modified 2002 Nissan Skyline GT-R R34^[5] from the Impound Lot. Dominic also shows up to race in his modified Chevelle. Gisele Yashar, the liaison for Braga, reveals that the winner will become the last driver on a team that traffics heroin between the Mexico–United States border. Dominic wins by bumping Brian's car while it is in nitro, making him lose control. Brian uses his power as an F.B.I. agent to arrest another driver, Dwight Mueller, and takes his place on the team.

The following day, the team meets one of Braga's men, named Fenix, and Dominic notices that Fenix drives the same Torino the mechanic described. They drive across the border using underground tunnels to avoid detection. Brian has prior knowledge that, after the heroin was delivered, Braga ordered the drivers to be killed. However, it is revealed to Dominic from Fenix that he killed Letty personally, and after a tense stand-off, Dominic detonates his car with nitrous to distract Braga's men, and Brian hijacks a 1999 Hummer H1 with $60 million worth of heroin in it. Both Dominic and Brian drive back to L.A. and hide the heroin in a police impound lot, where Brian picks up a modified 2008 Subaru Impreza WRX STI Hatchback, and they drive to Dominic's hideout.

Later, Dominic finds out Brian was the last person to contact Letty, which results in Dominic attacking Brian until Brian explains that Letty was working undercover for him, tracking down Braga in exchange for clearing Dominic's record. Brian tells his superiors that in exchange for Dominic's pardon, he will lure Braga into a trap, forcing him to personally show up to exchange money for the heroin. At the drop site, the man who claims to be "Braga", is revealed as a decoy, and "Campos", the real Braga, escapes and flees to Mexico.

Brian and Dominic travel to Mexico on their own to catch Braga. They find him at a church and apprehend him. As Braga's henchmen try to rescue him, Brian and Dominic drive through the underground tunnels back to the United States. Brian crashes his car after taking fire from Braga's men. He is then injured after being T-boned by Fenix at the end of the tunnel. Before Fenix can kill Brian, Dominic drives into and kills Fenix. As police and helicopters start approaching the crash site on the American side of the border, Brian tells Dominic to leave, but Dominic refuses, saying that he is tired of running. Despite Brian's request for clemency, the judge sentences Dominic to 25 years to life while Brian resigns from the F.B.I. Dominic boards a prison bus that will transport him to Lompoc penitentiary. As the bus drives down the road, Brian, Mia, Leo and Santos arrive in their cars to intercept it.