Tamami (Esumi Makiko) is a shrewd forensic pathologist who boldly acts according to her own convictions. She would do whatever it takes to reveal the truth behind the deaths of victims who have no voice, and pays no heed to the objections from those around her. But at home, she has trouble with household chores and communicating with her son, which makes her feel torn between work and family. Chika (Ishihara Satomi) is a career detective who does nothing at the police precinct. She wants success in work as well as marriage, but her life spins around in aimless circles. Even though the two of them face off each other over strange, unnatural deaths and get into conflicts because they are the least compatible, they unravel these mysteries as if they are speaking for the dead.
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江角真纪子在剧中饰演法医学者大达珠实,石原里美饰演刑警釜津田知佳,故事以这两位女子的冲突和对立为主线,讲述为追求事件真相工作的女人们的故事。
剧中女主角珠实对查明死因有强烈要求,她的目标是让死因解剖加入日本社会体系,为此还去美国留学两年,回到日本后她成为国立上都大学医学系法医学教室的副教授,为查明各种死因奔走,但作为法医学者她的很多行为让人不解,因此还成了警察要注意的人物。
而知佳则是个虽然很有经验却被左迁的刑警,她急切要立功,虽然她不重视死亡案件,但是遇到珠实之后她也开始理解查明死因的重要性。稻垣吾郎饰演的名仓润之助是知佳的恋人同时也和珠实一样是法医学教室副教授。